Gallic acid toxicity

Gallic acid toxicity. Compared with the control (without stress), the cell growth was severely retarded, and irregular cell The aim of this study is to determine the effect of GA on maize seedlings as well as its antioxidative effect under copper (Cu) stress. Gallic acid (GA), also known as 3,4,5-trihydroxybenzoic acid, is a natural secondary metabolite and widely isolated from various fruits, plants and nuts. ). Material/Methods Beas-2B cell viability was measured by MTT assay. Group 1 is the control group; The full mechanism of acorn toxicity is unknown; however, the toxicity of oak leaves and acorns is suspected to be due to high concentrations of tannins, including the poisonous metabolites pyrogallol and gallic acid . Its extensive health benefits, such as antimicrobial, antioxidant, anticancer, anti Subchronic toxicity of gallic acid (GA) was investigated in F344 rats by feeding diet containing 0, 0. Gallic acid prevents methotrexate-induced nephrotoxicity and sodium arsenite-induced toxicity in the rat's liver and kidney . To that end, maize seedlings were exposed to 1. of each sex Gallic acid and its derivatives such as lauryl gallate, propyl gallate, octyl gallate, tetradecyl gallate, and hexadecyl gallate are phenolic acids of plant metabolites widely spread throughout the plant kingdom. Gallic acid (GA), a phenolic acid found in fruits and vegetables, has been consumed by humans for centuries. [Google Scholar] Niho N. +49 34291 3372-36 Fax. Fourier Gallic acid is a trihydroxybenzoic acid with various biological activities and pharmacological properties. CdCl 2 alone was found to significantly (p < 0. Yadav N, Dubey A, Shukla S, et al. TOXICITY IRRITATION Oral (rabbit) LD50: 5000 mg/kg Nil Reported Oral (rat) LD50: 5000 mg/kg* [Manufacturer*]! Asthma-like symptoms may continue for months or even years after Quercetin and gallic acid are phytochemicals with interesting pharmacological properties. Therefore, we investigate the effect of different doses of GA alone and in the presence of BA on MSCs. 7 As shown in Figure 1, gallic acid is a trihydroxybenzoic acid in which the hydroxy groups are at positions 3, 4, and 5. Figure 1 shows the effects of a 21-day exposure to CdCl 2 and gallic acid on SOD, catalase, and GSH in the cerebrum of Wistar rats. Learn about its structure, sources, effects, mechanisms, and Acute toxicity of gallic acid was determined in albino mice and 28-days sub-acute toxicity study was carried out in male and female albino mice at three dose levels, 100, 300 and 900 Gallic acid could prevent neuronal death and increase the learning and passive avoidance memory. Adult female rats were daily administered with cadmium (CdCl 2) (5 mg/kg) singly or combined with GA (20 mg/kg) for 14 days to evaluate the effect on antioxidant status and ovary function using biochemical and histological analysis. Clinical trials of bioactive products, especially those of natural origin, is of great interest to explore the bioactivity and to aspire scientists for drug discovery. coli and coated with gallic acid. Consequently, this research aimed to examine the individual and The aims of the present study were to evaluate the protective effects of gallic acid against doxorubicin-induced ovarian toxicity in mice, and to verify the possible involvement of PI3K and mTOR signaling pathway members (PTEN, Akt, FOXO3a and rpS6) in the gallic acid protective actions. coli. GA dose-dependently decreased the growth of Calu-6 Gallic and tannic acid (the same type of toxins that we see in oak) cause destruction of red blood cells, called hemolysis. However, there is limited knowledge regarding its impact on the growth of M. Further, no appreciable change was noted in the various biochemical parameters such as SGOT and The absorption, metabolism, and distribution of GA. The degree of oxidative stress was detected by measuring the levels of reactive Gallic acid (GA) has antioxidant, anti-inflammatory and antimicrobial properties, while ellagic acid (EA) demonstrates anticancer, antiviral and photoprotective activity. Chemical Safety Data Sheet MSDS / SDS. 010 Corpus ID: 53774671; Acute and 28‐days repeated dose sub‐acute toxicity study of gallic acid in albino mice @article{Variya2019AcuteA2, title={Acute and 28‐days repeated dose sub‐acute toxicity study of gallic acid in albino mice}, author={Bhavesh C. Rats Wistar received Pb nitrate (50 mg/Kg/day, i. Toxicological parameters included clinical signs, body weight, food consumption, hematology, blood biochemistry, organ weights and histopathological assessment. This is the first report to comprehensively assess the toxicity of gallic acid on E. Gallic acid maintains survival and promotes in vitro development of sheep secondary follicles through the modulation of the phosphatidylinositol 3-kinase (PI3K) signaling pathway [21]. , Tamura T. Forty male institute of cancer research (ICR) mice were randomly divided into four groups: sham-veh, PD-veh (received subcutaneous i Purpose: This study aimed to investigate the protective effects of gallic acid (GA) against ovarian damage induced by bisphenol A (BPA) exposure in female rats. We delineate that gallic acid inhibits metal-induced aggregation by chelating the metal ions in the solvent, thereby inhibiting the aggregation of human lysozyme as demonstrated by our spectroscopic results which showed the formation of a complex between Mg 2+ and gallic acid. The primary aim of the study was to investigate gallic acid prompted PPAR-α/γ Gallic acid is a natural phenolic acid that has a stress inhibition effect on E. You can also browse global suppliers,vendor,prices,Price,manufacturers of Gallic acid(149-91-7). Subchronic toxicity of gallic acid was investigated in F344 . Present study was aimed to evaluate Gallic acid (GA) is an important phenolic compound possessing various pharmacological properties including anti-inflammatory, antioxidant and free radical scavenging activities. Its toxicity is derived from metabolic byproducts representing health hazards to consumers. Methods: Male Wistar rats were randomly assigned into six To evaluate the efficacy of gallic acid on paraquat-induced toxicity, forty-eight 6–8 week old male Wistar rats with an average weight of 200±20 were obtained from Pasteur Institute (Tehran, Iran). Gallate and galloyl derivatives of gallic acid are of natural origin and included among many food additives and drinks, and therefore the common practice shows their safety as well as their bioactivity [305]. 5 mM GA and 1 mM Cu solutions, and the seedlings were allocated to following experimental groups: 18-hr distilled wat Protective effects of gallic acid against Streptozotocin-induced oxidative damage in rat striatum. Here, we present in vivo findings on AFB 1 and GA on hepatorenal function in rats, exposed to AFB 1 (75 µg/kg body weight) only or co-treated with GA (20 or 40 mg/kg) A review of traditional uses, phytochemistry and pharmacology of the genus Indigofera. W3110, a commonly used str a in. Each group consisted of 10 rats of each sex. PMID: 14028469 No abstract available. com: Emergency telephone number: HPC Standards Tel. The biosynthetic origin of gallic acid was disputed for long time between an early derivate of shikimic acid and For the efflux pump inhibition results, only the compound gallic acid showed potentiating effect on antibacterial activity when associated with the substrate EtBr for the IS-58 strain carrying the TetK efflux pump. 62 In the intrahippocampal infusion of Aβ-induced rat model of Alzheimer’s disease, gallic acid treatment could improve the brain electrical activity and histological damage (removed the Alzheimer’s disease plaques in CA1 region of hippocampus) in a dose The protective role of gallic acid (GA) on reproductive toxicity induced by cyclophosphamide (CPA), an antineoplastic drug, was investigated in male Wistar rats. At the highest concentration of the metal (1. Likewise, gallic acid, found in abundance in green and black teas, appears to inhibit Aβ aggregation and protect living cells from Aβ toxicity . +49 34291 3372-36 This The effect of the antioxidant gallic acid (GA) on Pb toxicity in blood, liver and kidney was investigated in the present study. 1962 Nov;23:1264-7. GA, a phenolic acid has numerous beneficial properties, which include antiviral, antif The gallic acid coated silver nanoparticles (gSNP) showed excellent toxicity at 20 µg/ml IC50 towards SAOS-2 osteosarcoma cancer while less toxicity towards normal 3T3 cells. 2. Gallic acid is also a potent anti-oxidant phytochemical possessing numerous medicinal potentials against various ailments such as diabetes, hypercholesterolemia and other life-threatening diseases including malignancy. Effect of gallic acid or hesperidin on serum levels of kidney function biomarkers in AlCl3-induced toxicity in Wistar rats As shown in Fig. , 2004). GA has been applied in the food industry as an antimicrobial agent, food fresh-keeping agent, oil stabilizer, active food wrap material, and food processing stabilizer. Gallic acid has been found to be generally safe and effective for most cells at lower concentrations, but it becomes toxic at relatively higher concentrations (5). ABSTRACT Despite the therapeutic advances in treating malignancies, the efficient radiotherapeutic approaches with deprived adverse reactions still represent a potential clinical Request PDF | Gallic acid prevents 1, 2‐Dimethylhydrazine induced colon inflammation, toxicity, mucin depletion, and goblet cell disintegration | 1,2‐Dimethylhydrazine (DMH), an environmental In the present work, the effect of seed pre-soaking with gallic acid (GA; 3,4,5-triphydroxyl-benzoic acid) in conferring subsequent tolerance to Cd stress in sunflower (Helianthus annuus) seedlings was investigated. Objective: The present study purposed to study the protective effects of GA at 25 and 50 mg/kg against isoproterenol (ISO)-induced cardiac damage in ischemia/reperfusion (I/R) in rats. , 2015). Many alternative routes have been devised. Gallic acid, identified by Carl Wilhelm Scheele, is a grey powder with a sour taste that effervesces in calcium carbonate solution, is well soluble in ethanol and turns litmus red. Gallic acid is a phenolic compound that has antioxidant properties. At last,Gallic acid(149 The aims of the present study were to evaluate the protective effects of gallic acid against doxorubicin-induced ovarian toxicity in mice, and to verify the possible involvement of PI3K and mTOR signaling pathway members (PTEN, Akt, FOXO3a and rpS6) in the gallic acid protective actions. The mycotoxin ZEN contaminates crops, causing toxicity on ingestion, Gallic acid (GA) is an important phenolic compound, which could protect different tissues from oxidative stress induced damage. Rats in group B were administered DO A bottle of tannic acid (water solution) from the redwood tree. Nowadays, it is commonly known that a pure GA is a colorless, crystalline powder. Compared with the control (without stress), the cell growth was severely retarded, and irregular cell Material Safety Data Sheet or SDS for Gallic acid 149-91-7 from chemicalbook for download or viewing in the browser. Fish Husbandry and Embryo Collection T he d- wl i type zebra Effect of gallic acid or hesperidin on serum levels of kidney function biomarkers in AlCl3-induced toxicity in Wistar rats As shown in Fig. p Background Tartrazine (Tz) is one of the most commonly used colorants incorporated in the food manufacturing. 2013) was coupled to the Hecate peptide to evaluate the effect of gallic acid on the secondary structure, anti-cancer properties, toxicity, and hemolytic activity of the linear peptide Hecate. This substance is also able to prevent the kidneys from nephrotoxicity induced by Thus, it is reasonable to assume that high levels of antioxidants would be required to ameliorate DIC-induced toxicity. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. 41. This study aimed to determine the potential protective effect of gallic acid against nicotine-induced testicular toxicity in male mice. Gallic acid (GA, 3,4,5-trihydroxybenzoic acid, Fig. Revision Date:2024-10-26 Revision Number:1 SECTION 1: Identification of the substance/mixture and of the company/undertaking. To improve quality of AgNPs, different concentrations of gallic acid (ranging from 2. 1 , AlCl 3 significantly ( p < 0. Besides the fact that it is Gallic Acid Toxicity. Gallic acid is a phenolic acid ubiquitously present in numerous medicinal plants and food beverages. 05) reduce SOD, catalase, and GSH levels. LD 50 of gallic acid, known for various biological potentials, was more than 2000 mg/kg in mice. Toxicological Subchronic toxicity of gallic acid (GA) was investigated in F344 rats by feeding diet containing 0, 0. Grüner Tee enthält im Vergleich zum Schwarztee den zehnfachen Gehalt an Gallussäure und doppelt so viel wie Oolong-Tee. The present study was aimed to evaluate the efficacy of gallic acid (GA) against colon toxicity induced by DMH in Wistar rats. Also, the physicochemical, structural, and energetic properties of GA and the nanohybrids were determined through structure–activity relationship (SAR). Here, we present in vivo findings on AFB 1 and GA on hepatorenal function in rats, exposed to AFB 1 (75 µg/kg body weight) only or co-treated with GA (20 or 40 mg/kg) Objective: This study aimed to investigate the effects of gallic acid and silymarin against nephrotoxicity and hepatotoxicity caused by cisplatin. Our previous studies showed 6 ng/ml boric acid (BA) had positive effect on biochemistry of rat bone marrow mesenchymal stem cells (MSCs) and their osteogenic differentiation. In plants, gallic acid occurs in free form or in the form of esters (e. Each group consisted of 10 rats . As yet, the available toxicological Taken together, the neuroprotective effects of gallic acid on CdCl 2-induced toxicity in the brains of rats suggest its potent antioxidant and neurotherapeutic properties. Sixty rats were grouped into 10 rats per group. Forty rats were assigned randomly into two groups: control (ten Gallic acid reduces cardiac hypertrophy, dysfunction, Subchronic toxicity study of gallic acid by oral administration in F344 rats. In recent years, GA has received increasing attenti Gallic Acid Toxicity. Food Chem Toxicol 39, 1063–1070 (2001). Pertanika J Sci Tech. , 1994, Li et al. In this study, acute administration of gallic acid even at a dose as high as 5 g/kg body weight did not produce any signs of toxicity or mortality. caerula fruits, and methyl gallate was Utilizing the allelopathic effect of plants to inhibit algae growth has gained significant attention from researchers in recent years. 7 and 5% . Objective: As a herbicide, paraquat is a toxic agent that has devastating effects on human health. Reported LD50 values are 320 mg/kg (mouse, intravenous), 5000 mg/kg (rabbit, oral), and 4300 mg/kg (mouse, intraperitoneal). Cadmium is a highly neurotoxic heavy metal that disrupts membranes and causes oxidative stress in the brain. : 690558: Relevant identified uses of the substance or mixture: Identified: Laboratory chemical uses: R&D: Uses advised against: HPC Standards GmbH Am Wieseneck 7 04451 Cunnersdorf Deutschland Tel. Rats Gallic acid (trihydroxybenzoic acid) an abundantly available plant phenolic bioresource was utilized to establish a greener production of smaller sized (8±4 nm) stable silver nanoparticles (AgNPs), without any waste byproducts. The effect of GA on cell migration was evaluated using a Ellagic acid and gallic acid have been well-established as potent anticancer agents against various types of cancers, including GC. 8 mol per mol Nanoparticle encapsulation enhances Gallic Acid efficacy, reduces toxicity, and optimizes outcomes. Gallic acid . Moreover, biomarker analyses Gallic Acid | C7H6O5 | CID 370 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. ) was evaluated against beryllium-induced biochemical and morphological alterations in the liver and kidney. Male Wistar rats were Subchronic toxicity of gallic acid (GA) was investigated in F344 rats by feeding diet containing 0, 0. 2, 0. Toxicity assessment of gallic acid loaded graphene oxide (GAGO) nano-formulation in zebrafish (Danio rerio) embryos. , Toyoda K. Patel}, The adverse effect of Aflatoxin B1 (AFB 1) exposure in both humans and rodents has been widely reported. However, there are large amounts of microplastics in the aquatic environment, which may influence the inhibitory effects of allelochemicals on algae. pentagalloylglucose) – tannins (Kandra et al. Cardiovascular Effects of Gallic Acid. Gallic acid is a strong chelating agent and forms complexes of high stability with iron (III) (Sroka et al. Tannic acid is a specific form of tannin, a type of polyphenol. Gallic acid (GA) is a naturally occurring compound of many Gallic acid was practically non-toxic (96-h lethal concentration (LC50) > 100 mg/L) whereas pelargonic acid was slightly toxic (96-h LC50 of 81. Rats in groups 2 and 3 received GA alone at 60 and 120 mg kg −1 for 14 consecutive days, respectively. 11. 25 mM), this produced a better result in isolation than when it was associated with gallic acid, which may be explained by the fact that gallic acid has its own toxicity, such that when it was associated to the metal at this concentration, synergism occurred increasing in this way the overall The propyl, octyl and dodecyl esters of gallic acid have been studied extensively in a large number of animal experiments involving oral dosing. GA, gallic acid; 4-OMeGA, 4-O-methygallic acid; 3-OMeGA, 3-O-methygallic acid; H, M, and L represent the high, middle, and low content of GA in corresponding tissues and organs, respectively; the 4-OMeGA in black boxes represent that it is the primary metabolite of GA in different organs. The concentration of gallic Acute toxicity i. Exposing sunflower seedlings to increasing Cd concentrations (5, 10 and 20 μM) cause Gallic acid improves the antioxidant ability The adverse effect of Aflatoxin B1 (AFB 1) exposure in both humans and rodents has been widely reported. Advances in targeted cancer therapy have been promoted by the integration of nanotechnology and natural compounds. Among the major compounds found in MFCC, only gallic acid (GA) showed a protective role against CP while quercetin and caffeic acid alone were ineffective. The adult Wistar rats were assigned as control, BUS: was In this current study, 16 derivatives of gallic acid were docked against five selected non-structural proteins of SARS-COV-2 known to be a good target for finding small molecule inhibitors against the virus Physicochemical properties and toxicity risks assessment prediction was done via the OSIRIS property explorer software Visit ChemicalBook To find more Gallic acid(149-91-7) information like chemical properties,Structure,melting point,boiling point,density,molecular formula,molecular weight, physical properties,toxicity information,customs codes. Gallotannins originate from the esterification of the hydroxyls of the sugar core with gallic acid (3,4,5-trihydroxyl benzoic acid) that was discovered for the first time in the middle 1700s by a German chemist, Carl Wilhelm Scheele (Arapitsas 2012). 9 mg of AgNO 3 was dissolved in a 100 mL volumetric flask with deionized water and added to a 250 mL beaker. Gallic Acid Properties, Occurrence, and Production. In this study, gallic acid (You and Park 2010; Ho et al. 15 M, p. , 5 days) followed by GA (13. Methods: Twenty-eight male rats were randomly divided into four groups as control, MTX (20 mg/kg, Conclusion: The results of this study suggested that gallic acid possesses reinforcing effects on the antioxidant defense system and could be administered to reduce the toxicity of paraquat. " by Jamilly Erica Sousa Campelo et al. gallic acid for 13 weeks. In this work, the effects of gallic acid (GA) on hepatic injury caused by VPA were investigated. coli 3110 response to gallic acid. The chemical formula for commercial tannic acid is often given as C 76 H 52 O 46, which corresponds with decagalloyl glucose, but in fact it is a mixture of polygalloyl Gallic acid trimethyl ether Eudesmic acid is most directly synthesized by reaction of gallic acid with dimethyl sulfate. Gallic acid (GA), as a phenolic compound found in various plants, has different potential anticancer properties such as apoptosis induction, cell Gallic acid is a powerful antioxidant that possesses antimutagenic and anticancer activities. This study has revealed that as the GA concentration Gallic acid (GA) has antioxidant, anti-inflammatory and antimicrobial properties, while ellagic acid (EA) demonstrates anticancer, antiviral and photoprotective activity. The present paper reports results from the reaction of gallic acid (GA) with Cu(II) using electron paramagnetic resonance (EPR) and UV/visible spectroscopy for various relative concentrations and pH values. 2 Gallic acid and galloylation2. The rats were randomly divided into six groups of 10 animals per group. for producing high value-added product s by engineer i ng modi cation, Request PDF | Gallic acid inhibits celecoxib-induced mitochondrial permeability transition and reduces its toxicity in isolated cardiomyocytes and mitochondria | Background: Mitochondria are the CCl 4 toxicity is a fatal condition that can cause numerous organ dysfunctions. As gallic acid (GA) role in zearalenone (ZEN); mediated reproductive dysfunction has not been studied, we report on GA's effect on reproductive dysfunction in rats treated with ZEN-100 µg/kg alone, or with GA-40 mg/kg; for 4 weeks. Mice were pretreated with NaCl (0. Mice were p Gallussäure ist der Baustein der pflanzlichen Gerbstoffgruppe der Gallotannine und kommt z. Then, rats were randomly allocated to 6 different groups Taken together, the neuroprotective effects of gallic acid on CdCl2-induced toxicity in the brains of rats suggest its potent antioxidant and neurotherapeutic properties. The present study investigated effects of GA against sodium arsenite (SA)-induced spleno-, cardio- and hemato-toxicity. to Safe Work Australia - Code of Practice Gallic acid ≥98 %, p. Group 1 was the control group; group 2 was the group receiving cisplatin; group 3 was the group receiving cisplatin + gallic acid; This study aimed to determine the effect of gallic acid (GA) on ameliorating bisphenol A (BPA) nephrotoxicity in male rat kidneys. 50 to 11. In this study, the combination of these substances incorporated into a poloxamer gel was tested to verify the individual effect o Evaluation of the acute toxicity of ellagic acid and gallic acid 3. 7 macrophages as well as its therapeutic effects in an experimental dry eye (EDE) mouse model. Thirty-five rats were randomly divided in to five groups; group 1 was treated with normal saline (2 ml/kg/day, p. Background Gallic acid (GA) has a potential antioxidant bio-activity and inhibits diet-induced hypertriglyceridemia with reducing the size of adipocytes. Reference substance name: 3,4,5-trihydroxybenzoic acid EC Number: 205-749-9 EC Name: 3,4,5 Paraquat (PRQ) is a toxic chemical compound that is very noxious to animals and humans. Weiterhin finden sich relevante Mengen in Brombeeren, Himbeeren, schwarzen und weißen Gallic acid is also obtained from tannin. Toxicological Gallic acid is a natural phenolic acid that has a stress inhibition effect on Escherichia coli. Group 1 (control) received distilled water. On the other hand, CdCl 2, markedly (p < 0. Cadmium is a highly Quercetin and gallic acid are phytochemicals with interesting pharmacological properties. ) (control and doxorubicin Objective To evaluate the combination of rhubarb, astragalus, red sage, ginger, and turmeric (mixture referred to as “NT”) together with gallic acid for evidence of reproductive toxicity in rats. Bakrania and Prem Madan and Snehal S. p. in hair dye formulations, is declining because of concerns about its toxicity. 7 and 5% GA for 13 weeks. Despite its great effectiveness, this drug causes liver toxicity. Rats in group A received clean tap water ad libitum. [3] Pure pyrogallol was found to be extremely genotoxic when inserted into cultured cells, but α amylase proteins transferase for biotransformation related enzyme. Gallic acid (GA) is a naturally occurring compound of many plants that is used in the food, cosmetics, and drug industries. e. , Uneyama C. Gallic acid (GA), a phenolic substance, is a natural antioxidant with proven free radical scavenging activity and offers protection against oxidative damage. Our studies showed retention of lysozymal activity upto 63. This research The effect of Gallic acid (GA) on doxorubicin (DOX)-induced testicular and epididymal toxicity was investigated in experimental rat model. Dimethyl sulfoxide (DMSO) from Himedia, India. Before initiation of the study, rats could freely have water as well as food and they were kept at 25°C under a 12 hr dark-light cycle. Further analysis confirms the cell cycle inhibition takes place at S and G2/M phase while acridine orange and ethidium bromide (AO/EB) staining confirms the apoptosis, showed membrane Gallic acid mitigates diclofenac-induced liver toxicity by modulating oxidative stress and suppressing IL-1 Thus, it is reasonable to assume that high levels of antioxidants would be required to ameliorate DIC-induced toxicity. yrtph. 8R Specific target organ toxicity - single exposure (respirat-ory tract irritation) 3 STOT SE 3 H335 Safety data sheet Safety data sheet acc. , 2001). Acute toxicity of gallic acid was determined in albino mice and 28-days sub-acute toxicity study was carried out in male and female albino mice at three dose levels, 100, 300 and 900 mg/kg/day, p 2. Purpose: The present study investigates the stability, toxicity, and antibacterial potential of gallic acid-loaded graphene oxide (GAGO) on several PDF | On May 31, 2019, Zahra Mehraban published Protective Effect of Gallic Acid on Testicular Tissue, Sperm Parameters, and DNA Fragmentation against Toxicity Induced by Cyclophosphamide in Adult Terrestrial toxicity Endpoint summary; Toxicity to soil macroorganisms except arthropods; Toxicity to terrestrial arthropods; Toxicity to terrestrial Gallic acid - SIP State Form: solid: particulate/powder. E. Therefore, in this work we biosynthesize SNP from E. GA is Quercetin and gallic acid are phytochemicals with interesting pharmacological properties. We randomly divided 48 Wistar rats into 6 groups. , 3 days) or a chelating agent (EDTA, 55 mg/Kg, i. sehr reichhaltig in Eichenrinde und Galläpfeln vor. In the present work, the effect of seed pre-soaking with gallic acid (GA; 3,4,5-triphydroxyl-benzoic acid) in conferring subsequent tolerance to Cd stress in sunflower (Helianthus annuus) seedlings was investigated. Materials and methods: the viability of Gallic acid showed its anticholesterolemic effects through the inhibition of pancreatic cholesterol esterase by binding to bile acids and decreasing the solubility of cholesterol in micelles (Porat et al. Subchronic toxicity study of gallic acid by oral administration in F344 rats. Experimental data on general toxicity and studies on reproduction, teratogenicity and mutagenicity are also available. coli and provides new ideas for the study of microbial tolerance to environmental stress and the identification of associated tolerance targets. The second group received only However, there are no reports about the effects of gallic acid against doxorubicin-induced ovarian toxicity in mice. 2% in presence of gallic This study evaluates the probable effects of induced reproductive toxicity by cadmium and its amelioration by gallic acid (GA). Furthermore, the hydroxyl and carboxyl groups of gallic acid appear to play a critical role in Gallic acid can reduce the incidence of in˙ammation-related diseases, including cancer 24,25, raducioral scva esaes di 26,27 , liver disease 28,29 , n˙mai omni t a 30,31 , and neurodegenerative The reduction of silver ions from silver nitrate took place in the presence of a bioreducing agent, gallic acid, which is known as a phenolic acid naturally occurring in many land plants, fruits, and vegetables. 1. The effect of Gallic acid (GA) on doxorubicin (DOX)-induced testicular and epididymal toxicity was investigated in experimental rat model. Here, we present in vivo findings on AFB 1 and GA on hepatorenal function in rats, exposed to AFB 1 (75 µg/kg body weight) only or co-treated with GA (20 or 40 mg/kg) In this current study, 16 derivatives of gallic acid were docked against five selected non-structural proteins of SARS-COV-2 known to be a good target for finding small molecule inhibitors against the virus Kamil Kuca, in Food and Chemical Toxicology, 2022. Constituent 1. Rats in group B were administered DO Gallic acid (GA) is an important phenolic compound possessing various pharmacological properties including anti-inflammatory, antioxidant and free radical scavenging activities. GA is widely found However, there are no reports about the effects of gallic acid against doxorubicin-induced ovarian toxicity in mice. This study by integrates fermentation Quercetin and gallic acid are phytochemicals with interesting pharmacological properties. All MSDS PDF. Present study was aimed to evaluate Environmental Toxicology is an international journal addressing the toxicity & toxicology of environmental pollutants such as soil contamination and air & water pollution. [4] Butobendine; In addition, the AR aqueous extract increased the survival of Caenorhabditis elegans upon juglone-induced toxicity. Hence, Present study was aimed to evaluate acute and sub-acute toxicity of gallic acid in albino mice. , 2000). ) and propolis (200 mg kg(-1) p. We investigated the effect of gallic acid (Gal) against neurodegenerative pathophysiology relevant to Parkinsion's disease (PD) in mice with rotenone-induced toxicity. Gallic acid (GA) is an important phenolic compound, which could protect different tissues from Objective: As a herbicide, paraquat is a toxic agent that has devastating effects on human health. g. Female albino rats were exposed to beryllium nitrate (1 mg kg(-1) i. Gallic acid, on the other hand, is a natural compound that its anti-oxidant values have been Gallic acid and tannins from A. ChemicalBook. Another toxin, called pyrogallol, causes methemoglobinemia, which prevents red cells from being Gallic acid mitigates diclofenac-induced liver toxicity by modulating oxidative stress and suppressing IL-1 Thus, it is reasonable to assume that high levels of antioxidants would be required to ameliorate DIC Quercetin and gallic acid are phytochemicals with interesting pharmacological properties. 11 reported that GA inhibits pancreatic cholesterol esterase by binding to bile acids and reducing the solubility of cholesterol in micelles. As a result, adverse herbal–drug interactions may occur if ellagic acid and gallic acid supplements are taken concurrently with drugs that are CYP2D6 substrates . ) (control and doxorubicin GALLIC ACID TOXICITY AND IRRITATION GALLIC ACID:! unless otherwise specified data extracted from RTECS - Register of Toxic Effects of Chemical Substances. Day 0 of potential pregnancy was evidence of spermatozoa on vaginal smear. Rats 3. Methods: Thirty-two female rats Gallic acid is widespread in plant foods and beverages such as tea and wine and was proven to be one of the anticarcinogenic polyphenols present in green tea (Kerry and Abbey, 1997, Caccetta et al. Toxicology of Gallic Acid. As far as we know, this is the first study reporting the protective effect of MFCC against organophosphate The aims of the present study were to evaluate the protective effects of gallic acid against doxorubicin-induced ovarian toxicity in mice, and to verify the possible involvement of PI3K and mTOR signaling pathway members (PTEN, Akt, FOXO3a and rpS6) in the gallic acid protective actions. Semantic Scholar extracted view of "Evaluation of the acute toxicity of ellagic acid and gallic acid incorporated in Poloxamer407® gel, in Zophobas morio larvae. As many fundamental molecular pathways that control Aβ aggregation are yet to be unraveled, an important strategy to control Aβ cytotoxicity is the development of bioactive synthetic nanotools capable of interacting with the Gallic acid (GA) widely distributed in plants and foods has its various biological effects. This study inv estigate d the toxic e f fects of gallic acid stre ss on . Group The aims of the present study were to evaluate the protective effects of gallic acid against doxorubicin-induced ovarian toxicity in mice, and to verify the possible involvement of PI3K and mTOR signaling pathway members (PTEN, Akt, FOXO3a and rpS6) in the gallic acid protective actions. 4. Valproic acid (VPA) is one of the most broadly used drugs for epilepsy disorders worldwide. 2018. Elise Gerometta, Anne Gauvin-Bialecki, in Journal of Ethnopharmacology, 2020. In renal tissue, Cisplatin is converted into more reactive molecules. B. PMID: 29069994 Aim of this study was to evaluate the preventive effect of gallic acid (GA) on methotrexate (MTX)-induced oxidative stress in rat liver. MeSH terms Animals Gallic Acid* Gallic acid is a natural phenolic acid that has a stress inhibition effect on Escherichia coli. Its weak acidity (pK a around 6) is due to the numerous phenol groups in the structure. o. The embryonic medium (E3 medium) was prepared and toxicity approaches followed using standard methods from OECD guidelines-236. Gallic acid (GA) is known for its redox stabilizing, anti-apoptotic, and cytoprotective characteristics. In the present experiments, gallic acid induced toxicity by inhibiting proliferation at 40 mg/L, and had an effect on cell viability starting from 20 mg/L. aeruginosa as the GA concentration transitions from high to low during the HABs control process. Di- or polymerization reactions between Cu(II) and carboxylate groups of Gallic acid is a natural phenolic acid that has a stress inhibition effect on Escherichia coli. 25 mM), furthermore reaction kinetics Background: The impetuous usage of antibiotics has led to the perpetual rise of methicillin-resistant Staphylococcus aureus (MRSA), which has garnered the interest of potential drug alternatives, including nanomaterials. Ngamukote et al. We evaluated whether GA can mitigate the adverse effects of BPA on ovarian structure, inflammatory markers, oxidative stress, apoptosis, and reproductive hormone levels. , Shibutani M. 05) raised MDA Gallic acid modulates oxido-inflammatory response in acrylamide-induced hepato-renal toxicity Author links open overlay panel Omokolade Oluwaseyi Alejolowo a b , Alice Owolona Elias a , Onyekachi Sonia Eseagwu a , Charles Obiora Nwonuma a b , Omorefosa Osarenkhoe Osemwegie c 1,2-Dimethylhydrazine (DMH), an environmental toxicant specifically targets the colon. Results from our study revealed that the protective effect of gallic acid (GA) on SA-induced toxicity may result from the reduction of lipid peroxidation and NO production as well as elevation of antioxidant capacity The site is secure. 4 Hydroxybenzoic acids. Gallic acid could exhibit both prooxidant as well as antioxidant characteristics, and its prooxidant action is responsible for its potent anticancer and apoptosis inducing properties in most of the literature reports as follows. Acute toxicity Exposure route Endpoint Value Species Method Source oral LD50 >5,000 mg/kg mouse ECHA Skin corrosion/irritation Causes skin irritation. Toxicity. Therefore, the aim of this study is to explore The protective role of gallic acid (GA) on reproductive toxicity induced by cyclophosphamide (CPA), an antineoplastic drug, was investigated in male Wistar rats. 1) is one of the simplest plant phenolics. 5. ABSTRACT Despite the therapeutic advances in treating malignancies, the efficient radiotherapeutic approaches with deprived adverse reactions still represent a potential clinical Gallic acid: Catalog No. Cyclophosphamide (CP), a bifunctional alkylating agent used in chemotherapy has been reported to induce organ toxicity mediated by generation of reactive oxygen species and oxidative stress. The concentrations used for each compound were based on their quantities revealed in the chromatographic profile of the MFCC. Here, we investigated the anti-cancer effects of GA on Calu-6 and A549 lung cancer cells in relation to reactive oxygen species (ROS) and glutathione (GSH). Ellagic acid and gallic acid showed no toxicity on the model arthropod D. Characterized process carried out through Gallic acid (GA or 3, 4, 5- trihydroxybenzoic acid) is a compound found in several plants including, tea leaves, grapes, pineapple, and coriander. The protective role of gallic acid (GA) on reproductive toxicity induced by cyclophosphamide (CPA), an antineoplastic drug, was investigated in male Wistar rats. 05) lowered serum albumin levels in Wistar rats when compared with both control and animals treated with gallic acid or hesperidin. Acute toxicity Shall not be classified as acutely toxic. 2020;28:311–326. 2006). Acute toxicity i. In this study, we evaluated the ameliorative effect of gallic acid against PRQ-induced renal injury and oxidative stress. Red blood cells help carry oxygen around the body, so the combination of loss of red cells due to hemolytic Scope: We examined the biological effect of gallic acid (GA) as a nuclear factor (NF)-κB acetyltransferase inhibitor on microglial-mediated β-amyloid neurotoxicity and restorative effects on the Aβ-induced cognitive dysfunction. Gallic acid and maslinic acid combination showed protective activities against isoproterenol-administered cardiac toxicity in rats. Moreover, biomarker analyses indicated enhanced superoxide dismutase activ-ity in fish exposed to 20, 40 and 100 mg/L of gallic acid Among the compounds found by HPLC analysis, gallic acid, caffeic acid, and quercetin were assayed in an isolated and collective manner, to test the possible protection against the toxicity of CP. Experimental approach: In this in vivo study, forty-eight mice were equally divided into eight groups intraperitoneally receiving normal saline The combined effect of gallic acid (3,4,5-trihydroxy benzoic acid; GA; 50 mg kg(-1) i. Background This study aimed to explore the preventive effects of gallic acid (GA) on the toxicity induced by NiSO4 in Beas-2B cells. , et al. Compared with the control (without stress), the cell growth was severely retarded, and irregular cell Download Citation | On Nov 1, 2023, Jamilly Erica Sousa Campelo and others published Evaluation of the acute toxicity of ellagic acid and gallic acid incorporated in Poloxamer407® gel, in Background Gallic acid (GA) has a potential antioxidant bio-activity and inhibits diet-induced hypertriglyceridemia with reducing the size of adipocytes. It is also present in areca nuts, pineapples, strawberries and bananas [ Effect of gallic acid or hesperidin on serum levels of kidney function biomarkers in AlCl3-induced toxicity in Wistar rats As shown in Fig. These research results indicate that GA Gallic acid mitigates diclofenac-induced liver toxicity by modulating oxidative stress and suppressing IL-1 Thus, it is reasonable to assume that high levels of antioxidants would be required to ameliorate DIC-induced toxicity. In this research, the rats were segregated into six groups. Gallic acid is a natural phenolic acid that has a stress inhibition effect on Escherichia coli . Group 1 was considered as control. to Regulation (EC) No. 05) raised MDA Subchronic toxicity of gallic acid was investigated in F344 . When in combination, these compounds avoided the toxicity of CP at the same level as GA. We evaluated and compared the protective effects of cuminaldehyde (CuA), thymoquinone (TQ), and gallic acid (GA) on CCl 4-induced pulmonary and renal toxicity in rats. Gallic acid (GA), 3,4,5-trihydroxybenzoic acid, is a polyphenol compound and has gradually won a considerable amount of attention because it is ubiquitous in fruits, vegetables, and herbal Key findings. Another toxin, called pyrogallol, causes methemoglobinemia, which prevents red cells from being able to carry oxygen. Instead, ferulic acid was shown to be toxic at a lower dose of 10 mg/L, by inhibiting proliferation. Gallic acid, on the other hand, is a natural compound that its anti-oxidant values have been DOI: 10. , ACS article number: 2698 Version: 3. ) (control and doxorubicin Environmental Toxicology is an international journal addressing the toxicity & toxicology of environmental pollutants such as soil contamination and air & water pollution. +49 34291 3372-39 contact@hpc-standards. Gallic acid is bound to key proteins and minerals like iron, zinc, and calcium and affects its bioavailable complex through an insoluble complex. The aim of this study is to determine the effect of GA on maize seedlings as well as its antioxidative effect under copper (Cu) stress. 0 en Replaces version of: 2021-12-22 Version: (2) date of compilation: 2016-05-19 To investigate the anti-inflammatory and antioxidative effects of gallic acid (GA) on human corneal epithelial cells (HCECs) and RAW264. 5 mg/Kg, p. • Hematological, biochemical and morphological parameters did not show significant alteration in gallic acid treated mice. Variya and Anita K. As result, Pb decreased body weight, hematocrit and blood δ-aminolevulinic acid dehydratase Inhibition of oxidative stress may be a therapeutic approach for preventing SA-induced spleno-, hemato- and cardio-toxicity. Drug Research, 65 ( 10): 515–20. This study by integrates fermentation characteristics and transcriptional analyses to elucidate the physiological mechanism of E. ( 2001). Well, for the synthesis, 16. of each sex The self-assembly of amyloid-β (Aβ) generates cytotoxic oligomers linked to the onset and progression of Alzheimer’s disease (AD). Methods and results: The protective effects of GA on the survival of neuronal cells were assessed with an MTT assay and a co-culture system. A cell counting kit-8 (CCK-8) assay was used to test the cytotoxicity of GA. Surprisingly, we are unaware of studies showing tannic acid or gallic acid acting as inhibitors of IAPP aggregation. Materials and methods: In the study, 56 Wistar Albino rats were equally divided into eight groups. Di- or polymerization reactions between Cu(II) and carboxylate groups of The aim of this work was to evaluate antimicrobial activity against Paenibacillus larvae and oral toxicity against workers and larvae of Apis mellifera of gallic acid (GA) and two nanohybrids of GA and silica. Its derivatives have various length of Gallic acid (GA), a dietary phenolic acid with potent antioxidant activity, is widely distributed in edible plants. Silver nanoparticles (SNP) broad toxicity towards the cancer cells have attracted people to find the alternative anticancer agent. [2] Derivatives. Abstract. Therefore, the production of ROS, oxidative stress, accumulation of MDA, and depletion of antioxidant enzyme activity occur. The AR aqueous extract reduced apoptosis and increased the expression of phospho-Akt, The effect of the antioxidant gallic acid (GA) on Pb toxicity in blood, liver and kidney was investigated in the present study. Most of the key toxicity studies, ho Gallic acid (GA) is an allelochemical that has been utilized in high concentrations for the management of harmful algal blooms (HABs). As result, Pb decreased These results demonstrate that natural products such as gallic acid may be used for toxic metal chelation allowing plant development in polluted environments thus retrieving land usage for crops Kateřina Valentová, in Food and Chemical Toxicology, 2017. 1016/j. rubrum leaves have been implicated as the toxic compounds responsible for Red Maple Toxicosis (Boyer et al, 2002), but this study found that pyrogallol is a more potent inducer of methemoglobinemia. Therefore, gallic acid played a role against the brain oxidative stress resulting from lead poisoning. However, the compound induced hemorrhagic effects in chicken embryos, emphasizing the need for dose limitations. This study shows gallic acid can be encapsulated into MSN-GA and LB-MSN-GA nanoparticles with good loading capacities and encapsulation efficiency. Safety data sheet Safety data sheet acc. Beas-2B cell viability was measured by MTT assay. Jang et al. Toxicity studies on gallic acid indicate low acute and subacute toxicity. 6, 1. Its extensive health benefits, such as antimicrobial, including exposure to toxic agents, disruption of the electrochemical gradient (adenosine 5′-triphosphate (ATP) synthesis), Subchronic toxicity of gallic acid (GA) was investigated in F344 rats by feeding diet containing 0, 0. One preparation involves treating Pyrogallol use, e. [3] Trimebutine; Amoproxan; Bernzamide; 3,4,5-trimethoxy-N-(pyridin-4-yl)benzamide [31638-97-8]. 2 mg/L). We herein investigated the protective effect of quercetin (QUE) in comparison with gallic acid (GAL) against exogenously-induced oxidative damage in rats’ kidney and human embryonic kidney (HEK-293) cell lines. The Subchronic toxicity of gallic acid (GA) was investigated in F344 rats by feeding diet containing 0, 0. Methods Fifty virgin female rats were cohabited with male rats. melanogaster. In an acute oral toxicity study, no signs of lethal toxicity were observed at a dose of 5000 mg/kg. Purpose: This study aimed to investigate the protective effects of gallic acid (GA) against ovarian damage induced by bisphenol A (BPA) exposure in female rats. 10. This study aimed to explore the preventive effects of gallic acid (GA) on the toxicity induced by NiSO[4] in Beas-2B cells. The impacts of these compounds on CCl 4-induced oxidative stress, inflammation, and morphological alterations For this reason, our study has focused on determining the erythroprotective potential of fucoxanthin, β-Carotene, gallic acid, quercetin and ascorbic acid, representing biomolecules that belong to different families of antioxidants (carotenes, xanthophylls, phenolic acids, flavonoids and vitamins), with the aim of preventing or reducing oxidative stress Chemotherapeutic agents used to treat cancer cells does not kill cancer cells only but healthy cells as well. The beneficial health effects of gallic acid (GA) against AFB 1-induced toxicity in vitro have been published. The study aimed to investigate the neuroprotective effect of gallic acid on oxidative damage in the brains of Wistar rats exposed to cadmium chloride (CdCl₂). 7. The presumably pregnant rats Chronic exposure to toxic inorganic arsenic results in the adverse health effects including skin lesions, cardiovascular diseases, diabetes, neurological disorders, and liver and kidney diseases. 2 Clinical trials. Esterified with Deanol. An acute toxicological study was conducted by oral administration of both compounds alone (200, 1000, and 2000 mg/kg) and combined (2000 mg/kg) and their effects on the electron transport chain (ETC) and the ROS production in kidney mitochondria further In addition, we found that gallic acid, one of important phenolic constituents present in both extracts, could protect yeast cells against As(III) toxicity, likely through its role in decreasing As(III) accumulation and As(III)-induced ROS production. [10] Its LD 50 (oral, rat) is 300 mg/kg. 12 investigated the effect of GA, LA, a mixture of GA and LA (MGL), and chemically synthesized GA–LA ester (GLE) for its antihyperlipidemic action in Subchronic toxicity of gallic acid (GA) was investigated in F344 rats by feeding diet containing 0, 0. In this study, the combination of these substances incorporated into a poloxamer gel was tested to verify the individual effect o Evaluation of the acute toxicity of ellagic acid and gallic acid Gallic acid (3,4,5-trihydroxybenzoic acid) is a polyphenol that is commonly found in foods such as gallnuts, apple peels, oak bark, tea leaves, grapes, sumac, mango, lemon, and various berries. In the subacute study, gallic acid at a dose of 1000 mg/kg body weight did not significantly alter the hematological parameters. GA has been shown to have antioxidant, anti-inflammatory, antifungal, antiviral, anti-cancer, and anti-apoptotic properties. 5 mM GA and 1 mM Cu solutions, and the seedlings were allocated to following experimental groups: 18-hr distilled wat Gallic acid (GA) has antioxidant, anti-inflammatory and antimicrobial properties, while ellagic acid (EA) demonstrates anticancer, antiviral and photoprotective activity. 1907/2006 (REACH) Gallic acid monohydrate ≥98%, p. Exposing sunflower seedlings to increasing Cd concentrations (5, 10 and 20 μM) caused a gradual decrease in root and shoot biomass and Background: Gallic acid (GA) is a polyphenolic agent with interesting pharmacological impacts on the cardiovascular system. a. Chemicals Drug compounds for toxicity assessment (Quercetin, Gallic acid and Curcumin) were purchased from Sigma-Aldrich. Gallic acid has a The findings suggest that GA can be used to manage several neurological diseases and disorders, such as Alzheimer’s disease, Parkinson’s disease, strokes, sedation, A re-evaluation of the toxicity of gallates indicates that a 'classic' long-term toxicity study of propyl gallate meeting current standards is required. , Takahashi N. Product identifier. Acute toxicity of gallic acid was determined in albino mice and 28-days sub-acute toxicity study was carried out in male and female albino mice at three dose levels, 100, 300 and 900 mg/kg/day, p The adverse effect of Aflatoxin B1 (AFB 1) exposure in both humans and rodents has been widely reported. rats b y feedi ng diets containing 0, 0. Objective: Gallic acid (GA) and boron are found in many plants. Gallic acid is a natural phenolic compound that is widely found in gallnuts, sumac, tea, grapes, lemons, and other plants (it also appears in high concentration in green tea, red wine, coffee, and other beverages)(Choubey et al. . No alteration in transaminase and BUN level indicates hepato- and nephro-safety with use of gallic acid. Gallic acid. Benzoic acid, gallic acid (97) and methyl gallate (98) have been identified by HPTLC-MS in the methanol extract of I. This study integrates fermentation characteristics and transcriptional analyses to elucidate the Gallic acid (GA), a phenolic acid found in fruits and vegetables, has been consumed by humans for centuries. Gallic (GA) and ellagic (EA) acids are present in foods, medicinal plants, teas, and dietary supplements. Here, we studied the protective effect of gallic acid (GAL) as a potent anti-oxidant and anti-inflammatory agent against damage caused by busulfan (BUS) in the testes of adult rats. Gallic acid was practically non-toxic (96-h lethal concentration (LC 50) > 100 mg/L) whereas pelargonic acid was slight-ly toxic (96-h LC 50 of 81. Group Gallic Acid Toxicity. We herein investigated the protective effect of quercetin (QUE) in comparison with gallic acid (GAL) against exogenously-induced oxidative damage in rats' kidney and human embryonic kidney (HEK-293) cell lines. 30,31 Ellagic acid induces apoptosis and inhibits tumor growth 7 g Department of Toxicology, School of Pharmacy , Ahvaz Jundishapur University of Medical Sciences , Ahvaz , Iran. In this study, the combination of these substances incorporated into a poloxamer gel was tested to verify the individual effect of the substances, in addition to taking advantage of a probable The toxicity of gallic acid, pyrogallol, tannic acid, and Quercus havardi in the rabbit Am J Vet Res. ; for 21 . The degree of oxidative stress was detected by measuring the levels of reactive Gallic acid decarboxylase is unique among similar decarboxylases in that it requires iron as a cofactor, as shown by plasma emission spectroscopy (which revealed an iron content of 0. The present study investigated effects of GA against sodium arsenite (SA)-induced renal and hepatic toxicity. , ACS, anhydrous article Gallic and tannic acid (the same type of toxins that we see in oak) cause destruction of red blood cells, called hemolysis. Authors J W DOLLAHITE, R F PIGEON, B J CAMP. Gallic acid enhanced antioxidant status in cadmium chloride-induced Wistar rats. Reduction of Cu(II) by GA does not occur under strongly acidic or strongly alkaline conditions. Among the constituents of AR, only polysaccharides and gallic acid exhibited antioxidant and neuroprotective effects. Graphene oxide-coated surface: inhibition of bacterial biofilm formation due to specific surface-interface interactions. swc albu vublwtcq ipnpscr galxj kkibp bsyer udtmwn jaypae onyl